Offres d'emploi et de stages - Dynamique de la polarité épithéliale

Funded PhD position: Formation and maintenance of intestinal microvilli formation in C. elegans

We recently started to describe the growth and dynamics of microvilli during C. elegans development (Bidaud-Meynard et al, PMID: 34704594). We will next characterize how major microvilli components contribute to microvilli growth and maintenance and how their dynamic localization and behaviour are regulated during microvilli formation. To this end, we will use loss of function approaches and analyse the role of microvilli factors using a combination of super-resolution imaging, FRAP measurements and food absorption experiments. We will investigate the role of microvilli factors that we and others have already identified, as well as new microvilli components identified by our collaborator Mike Boxem (Utrecht University, Utrecht, Netherlands) using a proteomic approach. This project will lead to the first in-depth functional characterization of microvilli growth and maintenance in a living organism during embryonic and post-embryonic development, paving the way to future studies as a model for human intestinal diseases.

Supervised by anne [dot] pacqueletatuniv-rennes [dot] fr (Anne Pacquelet.)

How to apply to the PhD position

Context: one fully funded PhD position of the Horizon 2020 SurfEx Doctoral Network coordinated by Mike Boxem.

Start Date: from 1 September 2024

Application Closing Date: 15 March 2024

Condition to apply: candidates must hold a Master degree in developmental biology or cell biology and must not have resided or carried out their main activity (work, studies, etc.) in France for more than 12 months in the 36 months immediately before their date of recruitment. French speaking is not required.

How to apply: Send a CV, a motivation letter and the name of 2 references to anne [dot] pacqueletatuniv-rennes [dot] fr or gregoire [dot] michauxatuniv-rennes [dot] fr.

The successful applicants will be able to closely collaborate with the SurfEx teams of Mike Boxem, Lukas Kapitein and Silvia Mihăilă from Utrecht University; Fernando Martin Belmonte from CSIC; Mikael Sellin from Uppsala University; Thaher Pelaseyed from University of Gothenburg; Daniela Pacheco from Bac3Gel® Lda; Martin Knight from Queen Mary University of London; Daniel St Johnston from the University of Cambridge. They will also be integrated in the IGDR PhD program.