Séminaire externe - Philippe Chavrier


Regulation of the invadopodia, MT1-MMP-dependent matrix degradation program of cancer cells by mTORC1


Cancer cells use specialized protrusions termed invadopodia to localize matrix metalloproteinases for matrix degradation and invasion. The lecture will present evidence that invadopodia are self-assembling, force-producing proteolytic cell-matrix contacts that promote matrix pore enlargement to facilitate tumor cell invasion. I addition, I will discuss unpublished work that addressed the interplay between the mTOR kinase (mTORC1), a therapeutical target used in breast cancer management in clinics, and invadopodia function identifying an unprecedented role for transcription factor (TF)EB in the induction of a massive ECM degradation response in several models of breast cancer.