Reynald Gillet group - Quality Control in Protein Synthesis

In living organisms, most functions are performed by biomolecules called proteins. The synthesis of these proteins is carried out by a process called "translation" and is performed by the ribosome, a molecular machine present in all living cells. Our team studies the way bacteria produce proteins, using a combination of molecular biology, biochemistry, microbiology, cryo-electron microscopy and bioinformatics.

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Major publications

The structure of an elongation factor G-ribosome complex captured in the absence of inhibitors.
Macé K, Giudice E, Chat S, Gillet R.
Nucleic Acid Res. 2018 Apr.

A Genetic Tool to Quantify trans-Translation Activity in Vivo.
Macé K, Demay F, Guyomar C, Georgeault S, Giudice E, Goude R, Trautwetter A, Ermel G, Blanco C, Gillet R.
J. Mol. Biol. 2017 Nov.

Mechanism of eIF6 release from the nascent 60S ribosomal subunit.
Weis F, Giudice E, Churcher M, Jin L, Hilcenko C, Wong CC, Traynor D, Kay RR, Warren AJ.
Nat. Struct. Mol. Biol. 2015 Nov.

The task force that rescues stalled ribosomes in bacteria.
Giudice E, Gillet R.
Trends Biochem Sci. 2013 Aug.

Decoding in the absence of a codon by tmRNA and SmpB in the ribosome.
Neubauer C, Gillet R, Kelley AC, Ramakrishnan V.
Science. 2012 Mar.