Marie-Dominique Galibert group

The GEO team focuses on understanding the genetics mechanisms implicated in the transcriptional regulations that support tumour initiation and development. Two cancer diseases are under study : the UV-dependent skin cancers including melanoma and the ETV6/RUNX1-positive acute lymphoblastic leukemia (ALL) of child.

SELECTED PUBLICATIONS

  • The AhR-SRC axis as a therapeutic vulnerability in BRAFi-resistant melanoma.

Paris A*, Tardif N*, Baietti FM, Berra C, Leclair HM, Leucci E, Galibert MD*, Corre S*.
EMBO Mol Med. 2022 Dec 7;14(12):e15677. doi: 10.15252/emmm.202215677. Epub 2022 Oct 28. - * Equal contribution
 

  • ETV6-RUNX1 and RUNX1 directly regulate RAG1 expression: one more step in the understanding of childhood B-cell acute lymphoblastic leukemia leukemogenesis. 

Jakobczyk H*, Jiang Y*, Debaize L, Soubise B, Avner S, Sérandour AA, Rouger-Gaudichon J, Rio AG, Carroll JS, Raslova H, Gilot D, Liu Z, Demengeot J, Salbert G, Douet-Guilbert N, Corcos L, Galibert MD, Gandemer V, Troadec MB. 
​​​​​​​Leukemia. 2021 Sep 17. doi: 10.1038/s41375-021-01409-9. Online ahead of print. - * Equal contribution

  • USF1 defect drives p53 degradation during Helicobacter pylori infection and accelerates gastric carcinogenesis

Costa L, Corre S, Michel V, Le Luel K, Fernandes J, Ziveri J, Jouvion G, Danckaert A, Mouchet N, Da Silva Barreira D, Torres J, Camorlinga M, Milco D'Elios M, Fiette L, De Reuse H, Galibert MD*, Touati E*.
Gut. 2020 Sept. - * Equal contribution 

  • Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma. 

Corre S*, Tardif N*, Mouchet N, Leclair HM, Boussemart L, Gautron A, Bachelot L, Perrot A, Soshilov A, Rogiers A, Rambow F, Dumontet E, Tarte K, Bessede A, Guillemin GJ, Marine JC, Denison MS, Gilot D*, Galibert MD*.
Nat. Commun. 2018 Nov. - * Equal contribution 

  • Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation. 

Debaize L*, Jakobczyk H*, Avner S, Gaudichon J, Rio AG, Sérandour AA, Dorsheimer L, Chalmel F, Carroll JS, Zörnig M, Rieger MA, Delalande O, Salbert G, Galibert MD, Gandemer V, Troadec MB.
Nucleic Acids Res. 2018 Nov. - * Equal contribution 

  • A noncoding function of TYRP1 mRNA promotes melanoma growth. 

Gilot D*, Migault M*, Bachelot L, Journé F, Rogiers A, Donnou-Fournet E, Mogha A, Mouchet N, Pinel-Marie ML, Mari B, Montier T, Corre S, Gautron A, Rambow F, El Hajj P, Ben Jouira R, Tartare-Deckert S, Marine JC, Felden B, Ghanem G and Galibert MD. 
Nature Cell Biology. 2017 Nov. * Co-first author