Catherine André Group

To date, about 500 genetic diseases have been identify in the dog species. This diseases are spontaneous, breed specific with a high incidence in the affected breeds. In addition, most of them are homologous to human diseases. In this context, considerind dog as a patient, our research projects aim to the identification of the genetic basis of diseases affected both dogs and humans, with mutual genetic and therapeutic interest in both species.



Prouteau A, Denis JA, De Fornel P, Cadieu E, Derrien T, Kergal C, Botherel N, Ulvé R, Rault M, Bouzidi A, François R, Dorso L, Lespagnol A, Devauchelle P, Abadie J, André C, Hédan B. Circulating tumor DNA is detectable in canine histiocytic sarcoma, oral malignant melanoma, and multicentric lymphoma.   Sci Rep. 2021 Jan 13;11(1):877. doi: 10.1038/s41598-020-80332-y.

Hédan B, Rault M, Abadie J, Ulvé R, Botherel N, Devauchelle P, Copie-Bergman C, Cadieu E, Parrens M, Alten J, Zalcman EL, Cario G, Damaj G, Mokhtari K, Le Loarer F, Coulomb-Lhermine A, Derrien T, Hitte C, Bachelot L, Breen M, Gilot D, Blay JY, Donadieu J, André C. PTPN11 mutations in canine and human disseminated histiocytic sarcoma. Int J Cancer. 2020 Sep 15;147(6):1657-1665. doi: 10.1002/ijc.32991. Epub 2020 Apr 8. PMID: 32212266 Free article.

Ostrander EA, Wang GD, Larson G, vonHoldt BM, Davis BW, Jagannathan V, Hitte C, Wayne RK, Zhang YP; Dog10K Consortium . Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and health. Natl Sci Rev. 2019 Jul;6(4):810-824. doi: 10.1093/nsr/nwz049. Epub 2019 Apr 10. PubMed PMID: 31598383; PubMed Central PMCID: PMC6776107.

Prouteau A, Chocteau F, de Brito C, Cadieu E, Primot A, Botherel N, Degorce F, Cornevin L, Lagadic MA, Cabillic F, de Fornel-Thibaud P, Devauchelle P, Derrien T, Abadie J, André C, Hédan B. Prognostic value of somatic focal amplifications on chromosome 30 in canine oral melanoma. Vet Comp Oncol. 2020 Jun;18(2):214-223. doi: 10.1111/vco.12536. Epub 2019 Sep 13. PMID: 31461207

Prouteau A, André C. Canine Melanomas as Models for Human Melanomas: Clinical, Histological, and Genetic Comparison. Genes (Basel). 2019 Jun 30;10(7). pii: E501. doi: 10.3390/genes10070501. Review. PubMed PMID: 31262050; PubMed Central PMCID: PMC6678806.

Hitte C, Le Béguec C, Cadieu E, Wucher V, Primot A, Prouteau A, Botherel N, Hédan B, Lindblad-Toh K, André C, Derrien T. Genome-Wide Analysis of Long Non-Coding RNA Profiles in Canine Oral Melanomas. Genes (Basel). 2019 Jun 23;10(6). pii: E477. doi: 10.3390/genes10060477. PubMed PMID: 31234577; PubMed Central PMCID: PMC6628375.

Hédan B, Cadieu E, Botherel N, Dufaure de Citres C, Letko A, Rimbault M, Drögemüller C, Jagannathan V, Derrien T, Schmutz S, Leeb T, André C. Identification of a Missense Variant in MFSD12 Involved in Dilution of Phaeomelanin Leading to White or Cream Coat Color in Dogs. Genes (Basel). 2019 May 21;10(5). pii: E386. doi: 10.3390/genes10050386. PubMed PMID: 31117290; PubMed Central PMCID: PMC6562630.

Correard S, Plassais J, Lagoutte L, Botherel N, Thibaud JL, Hédan B, Richard L, Lia AS, Delague V, Mège C, Mathis S, Guaguère E, Paradis M, Vallat JM, Quignon P, André C. Canine neuropathies: powerful spontaneous models for human hereditary sensory neuropathies. Hum Genet. 2019 Apr 6. doi: 10.1007/s00439-019-02003-x. PubMed PMID: 30955094.

Le Béguec C, Wucher V, Lagoutte L, Cadieu E, Botherel N, Hédan B, De Brito C, Guillory AS, André C, Derrien T, Hitte C. Characterisation and functional predictions of canine long non-coding RNAs. Sci Rep. 2018 Sep 7;8(1):13444. doi: 10.1038/s41598-018-31770-2. PMID: 30194329; PMCID: PMC6128939.

Ulvé R, Rault M, Bahin M, Lagoutte L, Abadie J, De Brito C, Coindre JM, Botherel N, Rousseau A, Wucher V, Cadieu E, Thieblemont C, Hitte C, Cornevin L, Cabillic F, Bachelot L, Gilot D, Hennuy B, Guillaudeux T, Le Goff A, Derrien T, Hédan B, André C. Discovery of Human-Similar Gene Fusions in Canine Cancers. Cancer Res. 2017 Nov 1;77(21):5721-5727. doi: 10.1158/0008-5472.CAN-16-2691. Epub 2017 Sep 7. PMID: 28883003.

Wucher V, Legeai F, Hédan B, Rizk G, Lagoutte L, Leeb T, Jagannathan V, Cadieu E, David A, Lohi H, Cirera S, Fredholm M, Botherel N, Leegwater PAJ, Le Béguec C, Fieten H, Johnson J, Alföldi J, André C, Lindblad-Toh K, Hitte C, Derrien T. FEELnc: a tool for long non-coding RNA annotation and its application to the dog transcriptome. Nucleic Acids Res. 2017 May 5;45(8):e57. doi: 10.1093/nar/gkw1306. PMID: 28053114; PMCID: PMC5416892.

Plassais J, Lagoutte L, Correard S, Paradis M, Guaguère E, Hédan B, Pommier A, Botherel N, Cadiergues MC, Pilorge P, Silversides D, Bizot M, Samuels M, Arnan C, Johnson R, Hitte C, Salbert G, Méreau A, Quignon P, Derrien T, André C. A Point Mutation in a lincRNA Upstream of GDNF Is Associated to a Canine Insensitivity to Pain: A Spontaneous Model for Human Sensory Neuropathies. PLoS Genet. 2016 Dec 29;12(12):e1006482. doi: 10.1371/journal.pgen.1006482. PMID: 28033318; PMCID: PMC5198995.

Plassais J, Guaguère E, Lagoutte L, Guillory AG, Dufaure de Citres C, Degorce Rubiales F, Delverdier M, Vaysse A, Quignon P, Bleuart C, Hitte C, Fautrel A, Kaerle C, Bellaud P, Bensignor E, Queney G, Bourrat E, Thomas A* and André C*. A spontaneous KRT16 mutation in a dog breed: a model for human Focal Non Epidermolytic Palmoplantar Keratoderma (FNEPPK). J Invest Dermatol. 2015 Apr;135(4):1187-90.

Gillard M*, Cadieu E*, De Brito C, Abadie J, Vergier B, Devauchelle P, Degorce F, Dreano S, Primot A, Dorso L, Lagadic M, Galibert F, Hédan B, Galibert MD, and André C. Naturally occurring melanomas in dogs as relevant models for human melanomas. Pigment Cell & Melanoma Research 2014, 2014 Jan;27(1):90-102.

Grall A, Guaguère E, Planchais S, Grond S, Bourrat E, Hausser I, Hitte C, Le Gallo M, Derbois C, Kim GJ, Lagoutte L, Degorce-Rubiales F, Radner FP, Thomas A, Kury S, Bensignor E, Fontaine J, Pin D, Zimmermann R, Zechner R, Lathrop M, Galibert F, André C, Fischer J. PNPLA1 mutations cause autosomal récessive congenital ichthyosis in golden retriever dogs and humans. Nat Genet. 2012 Jan15;44(2):140-7.

Derrien T, Vaysse A, André C, Hitte C. Annotation of the domestic dog genome sequence: finding the missing genes. Mamm Genome. 2012 Feb;23(1-2):124-31.

Berglund J, Nevalainen EM, Molin AM, Perloski M; LUPA Consortium, André C, Zody MC, Sharpe T, Hitte C, Lindblad-Toh K, Lohi H, Webster MT. Novel origins of copy number variation in the dog genome. Genome Biol. 2012 Aug 23;13(8):R73. doi: 10.1186/gb-2012-13-8-r73. PMID: 22916802; PMCID: PMC4053742.